New PDF release: Biotechnology in Healthcare: An Introduction to

By Gavin Brooks

ISBN-10: 0853693722

ISBN-13: 9780853693727

ISBN-10: 085369799X

ISBN-13: 9780853697992

This paintings deals an advent to the ways that biotechnology can play a task in healthcare together with pharmacology. It offers a historical past in molecular biology and overviews ideas equivalent to gene cloning, gene remedy, transgenic animals and medical treatment examples.

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Therefore, a line of genetically identical cells (clones) containing the new DNA will be generated. , 1992). Uses of gene cloning The cloning of genes and their subsequent introduction into cells in vitro has been of considerable use in classical genetics, in that it has allowed greater analysis of gene structure and function. However, it has also had a significant effect on healthcare, and promises much more for the future. Some of these potential uses are described below. Recombinant proteins Where gene cloning has had perhaps the greatest impact on healthcare is in the production of recombinant proteins.

Together with epidemiological factors, such as late age of disease onset, this restricts the resolution of genetic studies to broad regions of interest, no smaller than 2–5 cM for small-effect genes. Tests for linkage in complex diseases require approaches that not only make no assumptions about the mode of inheritance, but also provide sufficient statistical power to detect weak alleles. In such cases, linkage studies apply genome-wide searches using highly polymorphic genetic markers, together with specific statistical programs.

Dinucleotide CA repeats are most common, but trinucleotide and tetranucleotide repeats are also informative. Importantly, PCR-based approaches for STRP mapping have been developed. 3 Restriction fragment length polymorphisms. DNA polymorphisms provide the major means of discriminating allelic markers. The principles underlying RFLPs are shown. The restriction enzyme EcoRI cuts genomic DNA specifically at the nucleotide sequence GAATTC. At a given genetic locus, variation of a single nucleotide is sufficient to create or destroy an EcoRI restriction site to generate two distinct alleles (A or a).

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Biotechnology in Healthcare: An Introduction to Biopharmaceuticals by Gavin Brooks


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