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ISBN-10: 3131534311

ISBN-13: 9783131534316

ISBN-10: 3131666412

ISBN-13: 9783131666413

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1 Leukoz y te n , das di e Anh ef t ung a n End oth elzellen erm ö gli cht . Bei Menschen Das Kompl e me nt sys tem ist e in e komplexe Gr upp e mit mehr a ls 20 vo n der Leber ge bild et e n sog. Komplementfaktoren (Plas maproteinen), di e s ich a ls inaktive Vorstufen im Blut befinden . Be i Aktivie run g dieses System s wird, ä hnli c h wi e bei der Blut- des HLA-Typ s DR' 0401 wi rd ein Prot ein des Bakterium s präsentie rt. das in eine m kur zen Abschnitt hom olog zu ein em Bereich von LFA-1 ist.

Lipopolysaccharide. bindet. Das C3b auf der Bakterienoberfläche wird dann von Faktor B gebunden. Faktor B hat eine ähnliche Funktion im alternativen Aktivierungsweg wie C2 im kla ssischen Weg: Faktor B und C3b lagern sich Mg 2 •-abhängig zu einem Komplex zu sammen. Dann wird Faktor B von Faktor D, einer Serinprotease, gespalten, und es entsteht eine aktive C3/C5-Konvertase (Abb. 12). Diese ist zwar nicht identisch mit der im klassischen Weg vorkommenden C3/C5-Konvertase, hat aber eine vergleichbare Wirkung.

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Biochemie. 3

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