Bioactive Peptides - download pdf or read online

By John Howl, Sarah Jones

ISBN-10: 1420061143

ISBN-13: 9781420061147

ISBN-10: 142006116X

ISBN-13: 9781420061161

Focuses on Biology, Pharmacology, and healing Applications

The research and numerous purposes of bioactive peptides traverse many sub-disciplines inside of chemistry, biology, physics, and medication. Answering a long-standing desire, Bioactive Peptides makes a speciality of the biology, pharmacology, and healing functions of endogenous peptide mediators and their analogues. relocating peptide technology past chemical synthesis innovations and into the nation-states of peptide biology and therapeutics, it offers the final contribution that peptide technological know-how has made to molecular, mobile, and full organism biology, whereas additionally discussing destiny objectives and healing applications.

Beneficial for specialists and newbies Alike

Part I offers info of bioactive peptides that engage with universal drug objectives and analyzes essentially the most aggressive parts of present examine all over the world. whereas it truly is widely recognized that mammalian physiological platforms make the most of bioactive peptides that experience but to be stumbled on, different animals supply a wealthy and useful resource of bioactive peptides. This interesting zone of technological know-how is the subject matter of half II. Parts III and IV examine the original bioactivities of assorted peptides which are ripe for extra exploration.

This definitive reference additionally includes:

  • A particular description and research of a wide diversity of peptides that engage with G protein-coupled receptors, the quantitatively dominant drug target
  • A dialogue of non-ribosomal peptides, which carry promise as resources of endogenous mediators
  • Important examples of universal methodologies hired to spot, represent, and extra boost bioactive peptides from various average sources

With mounting around the globe curiosity of their healing capability, bioactive peptides—including the identity of latest species, the synthesis of structural analogues, and numerous purposes in biology and medicine—will most probably stay on the leading edge of clinical exercise for lots of many years. delivering even informal readers with a wide style of the character and purposes of peptides, this quantity draws and excites tomorrow’s researchers who're charged with extra constructing and enforcing the findings awarded herein.

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Additional resources for Bioactive Peptides

Example text

Analysis of the cellular expression pattern of beta-CGRP in alphaCGRP-deficient mice, J. Comp. , 476, 32–43, 2004. , Calcitonin, Curr. Med. , 6, 1067–1093, 1999. C. , Effects of prolonged infusion of human alpha calcitonin gene-related peptide on hemodynamics, renal blood flow, and hormone levels in congestive heart failure, Am. J. , 67, 732–736, 1991. Shimosawa, T. , Adrenomedullin, an endogenous peptide, counteracts cardiovascular damage, Circulation, 105, 106–111, 2002. Shindo, T. , Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene, Circulation, 104, 1964–1971, 2001.

Szabó, A. , 58, 292–301, 2008. Taboulet, J. , Calcitonin receptor polymorphism is associated with a decreased fracture risk in postmenopausal women, Hum. Mol. , 7, 2129–2133, 1998. Takei, Y. , 556, 53–58, 2004. A. , Characterization and effects on cAMP accumulation of adrenomedullin and CT generelated peptide (CGRP) receptors in dissociated rat spinal cord cell culture, Br. J. , 148, 459–468, 2006. Tilakaratne, N. , Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment, J.

3, 126–129, 2002. Li, J. , Activation of the renin–angiotensin system in alpha-CT gene-related peptide/CT gene knockout mice, J. , 22, 1345–1349, 2004. Li, M. , Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice, J. Clin. , 116, 2653–2662, 2006. , Expression cloning of an adenylate cyclase-coupled calcitonin receptor, Science, 254, 1022–1024, 1991. Lorenzo, A. , Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red, Proc.

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Bioactive Peptides by John Howl, Sarah Jones

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