By Sarah Jane George, Jason Johnson
Overlaying the main devastating illness within the Western global, this guide and prepared reference offers a accomplished account of the several phases and components within the improvement of the atherosclerotic plaque. each one bankruptcy is written by means of specialists within the box and highlights the position of particular mediators of atherosclerotic plaque improvement, in addition to power healing objectives. a large number of this up to date details is conveyed in terms of tables and schematic figures, in a effortlessly understandable demeanour. essential for grasp and PhD scholars, researchers, MDs and teachers in vascular biology and cardiology, in addition to for lecturers and scientists within the pharmaceutical undefined.
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Additional resources for Atherosclerosis: Molecular and Cellular Mechanisms
2004) The accumulation of speciﬁc types of proteoglycans in eroded plaques: a role in coronary thrombosis in the absence of rupture. Curr. Opin. , 15 (5), 575–582. T. (2006) Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion. Coron. , 17 (7), 611–621. 21 PART II PRO-Inﬂammatory Factors Atherosclerosis: Molecular and Cellular Mechanisms. Edited by Sarah Jane George and Jason Johnson Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim ISBN: 978-3-527-32448-4 23 2 Chemokines and Atherosclerosis: A Critical Assessment of Therapeutic Targets Gemma E.
1992) A deﬁnition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association. Arterioscler. , 12 (1), 120–134. , et al. (1995) A deﬁnition of advanced types of atherosclerotic lesions and a histological classiﬁcation of atherosclerosis: a report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association. Arterioscler. Thromb. Vasc.
1 Atherosclerotic plaque formation. A: Normal artery wall is composed of the intima – a layer of endothelial cells seated on the internal elastic lamina – and the media, where vascular smooth muscle cells (VSMCs) are embedded in extracellular matrix and surrounded by the external elastic lamina. B: Endothelial dysfunction. Damage to the endothelium results due to exposure to risk factors and leads to the presence of reactive oxygen species (ROS), upregulation of adhesion molecules, and increased permeability.
Atherosclerosis: Molecular and Cellular Mechanisms by Sarah Jane George, Jason Johnson