By John Albano
Archie's Double Digest #155 - November 2004
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Additional info for Archie's Double Digest 155 (November 2004)
It measures how well a test identiﬁes truly ill people. 19. The correct answer is B. A retrospective cohort study includes a group of subjects who had some condition or received some treatment that is followed over time and compared to another group (a control group) made up of subjects who did not have this condition or receive the treatment. Retrospective cohort studies are based on the presence or absence of risk factors. In this study, the risk factor is the presence of diabetes in the mothers and the outcome would be LGA babies.
A mutation in the enhancer region of a gene does not cause xeroderma pigmentosum. Answer E is incorrect. A mutation in the operator region of a gene does not cause xeroderma pigmentosum. Answer F is incorrect. A mutation in the promoter region of a gene does not cause xeroderma pigmentosum. 2. The correct answer is B. Citrate, formed from oxaloacetate and acetyl CoA by the enzyme citrate synthase, inhibits phosphofructokinase and allosterically activates acetyl CoA carboxylase. Citrate synthase regenerates a molecule of CoA and is an important regulator of the tricarboxylic acid cycle.
Unlike the Iowa tests, which are given in a group setting to almost every child in the United States, the Wide-Range Achievement Test is used for individual testing. 10. The correct answer is C. The probability of having a condition, given a positive test, represents the positive predictive value. This is calculated by TP / (TP + FP), where TP means true-positive and FP means false-positive. Therefore, the positive predictive value is 180 / (180 + 40), or 82%. As the prevalence of the disease increases in a population, so does the positive predictive value.
Archie's Double Digest 155 (November 2004) by John Albano