By Kewal K. Jain
Culling jointly excerpts from a variety of writings by way of Dr. Kewal okay. Jain on biotechnology themes as they relate to problems of the anxious method, Applications of Biotechnology in Neurology covers numerous functions for these operating in lifestyles sciences and the pharmaceutical sciences, relatively these constructing diagnostics and therapeutics for the anxious approach. This designated quantity delves into parts corresponding to neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, a variety of tools of bettering systemic management of substances for exact supply to the apprehensive approach, together with using nanobiotechnology, biotechnology-based concepts and items for neuroprotection, in addition to chapters on neurosurgery and custom-made neurology.
Thorough, state-of-the-art, and thoughtfully equipped, Applications of Biotechnology in Neurology serves as an excellent advisor, supplemented by means of seventy five tables and sixteen figures in addition to a number of references from contemporary literature in this subject, that are appended to every chapter.
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Proteomics parallels the related ﬁeld of genomics. Now that the human genome has been sequenced, we face the greater challenge of making use of this information for improving healthcare and discovering new drugs. There is an increasing interest in proteomics technologies now because DNA sequence information provides only a static snapshot of the various ways in which the cell might use its proteins whereas the life of the cell is a dynamic process. With this background, DNA/RNA (ribonucleic acid) sequences, per se, are not enough for the clear identiﬁcation of a therapeutic target because proteins and not DNA/RNA are the basis of mode of action of drugs.
2006). Proteomics for Study of Neurological Disorders 23 Bovine Spongiform Encephalopathy Prion proteins speciﬁc to BSE have previously been found in various tissues of infected animals. Evidence of the disease-speciﬁc prion protein in the tissue always means the presence of infectivity and can therefore serve as a reliable indicator in a diagnostic test. The highest amounts of PrPBSE and the highest levels of infectivity are found in the brain and spinal cord. BSE can be detected by Prionics-Check test (Prionics AG/Roche Diagnostics), which is approved in Europe.
Protein can be detected by Western blot or ﬂuorescence detection methods. The proteins are then analyzed and characterized using mass spectrometry (MS) and its modiﬁcation, matrix-assisted laser desorption mass spectrometry (MALDI-MS). Other methods used include capillary electrophoresis (CE), high-performance liquid chromatography (HPLC), and electrospray ionization (ESI). The technologies are described in detail in a special report on proteomics (Jain 2012). The most comprehensive source of information on proteomics is found in protein sequence databases.
Applications of Biotechnology in Neurology by Kewal K. Jain