By Karsten Schrör
Written by means of a number one professional on Aspirin-related examine, this can be the main finished treatise at the pharmacological results and scientific purposes of 1 of the main profitable medications ever.
The textual content is written with a large viewers in brain, and to be quite simply comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised version comprises the most recent result of scientific and pharmacological examine on Acetylsalicylic acid, addressing the a number of pharmacological houses of this recognized drug with a balanced view on their translation into medical perform, together with prevention from cardiovascular ailments and colorectal cancer.
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Extra info for Acetylsalicylic Acid
This provides unlimited amounts of the compound independent of natural sources for medical use. 1875 Ebstein and M€ uller detect the blood sugar-lowering action of salicylates. 1876 Stricker introduces salicylate as an analgesic/antirheumatic drug at the Charite in Berlin. Shortly thereafter, Scottish physician MacLagan and Frenchman Germain See from Strassburg (Alsace) also describe an antipyretic/analgesic activity of the compound. 1897 Felix Hoffmann, working in the pharmaceutical research group at Bayer laboratories in Elberfeld under direction of Arthur Eichengr€ un, synthesizes for the ﬁrst time acetylsalicylic acid as a chemically pure and stable compound.
B. -B. -B. -B. 9 According to predeﬁned quality standards, the content of the active ingredient should be 95–105% of declaration and at least 80% of the compound should be released within 30 min under the conditions chosen. References The authors repeated this study 2 years later on 62 different aspirin preparations. ) still did not meet the quality standards mentioned above . Thus, Summary Aspirin and its main metabolite salicylic acid are poorly water soluble at acidic and neutral pH. The solubility increases markedly in alkaline pH and is more than 100-fold higher for the sodium salts as compared to the free acids.
1967) Salicylates and bleeding. The aspirin tolerance test. The American Journal of the Medical Sciences, 252, 265–269. E. et al. (1968) The effect of acetylsalicylic acid on platelet function. The Journal of Experimental Medicine, 128, 877–894. J. M. (1967) Impaired platelet–connective tissue reaction in man after aspirin ingestion. The Lancet, 2, 495–497. R. (1968) Effects of salicylates on human platelets. The Lancet, 1, 779–783. M. and Kochwa, S. (1968) The effects of salicylates on the hemostatic properties of platelets in man.
Acetylsalicylic Acid by Karsten Schrör