ABC Transporters: Biochemical, Cellular, and Molecular by John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, PDF

By John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, Michael M. Gottesman

ISBN-10: 0076687929

ISBN-13: 9780076687923

ISBN-10: 0121821935

ISBN-13: 9780121821937

The significantly acclaimed laboratory common for greater than 40 years, Methods in Enzymology is without doubt one of the such a lot hugely revered guides within the box of biochemistry. because 1955, every one quantity has been eagerly awaited, often consulted, and praised via researchers and reviewers alike. greater than 285 volumes were released (all of them nonetheless in print) and lots more and plenty of the cloth is appropriate even today-truly an important book for researchersin all fields of lifestyles sciences.

Key Features
* Prokaryotic ABC Transporters
* Eukaryotic ABC Transporters
* Nonmammalian ABC shipping Systems
* Mammalian P-Glycoproteins
* Multidrug Resistance linked Protein
* Cystic Fibrosis Transmembrane Conductance Regulator
* Sulfonylurea Receptor
* Intracellular ABC Transporters

Show description

Read or Download ABC Transporters: Biochemical, Cellular, and Molecular Aspects PDF

Similar cell biology books

Download e-book for iPad: Biology of Oral Cancer: Key Apoptotic Regulators by Prakash S. Bisen

Melanoma is a category of ailment or problems characterised via out of control department of cells and the facility of those cells to invade different tissues. One new technique in facing melanoma is thru apoptotic regulators, that's the method of controlling telephone progress by means of abnormally prolonging mobilephone survival, facilitating the buildup of reworking mutations and selling resistance.

Micropatterning in Cell Biology Part A - download pdf or read online

This new quantity of tools in phone Biology seems at micropatterning in cellphone biology and comprises chapters on protein photo-patterning on PEG with benzophenone, laser-directed mobilephone printing and dip pen nanolithography. The state-of-the-art fabric during this finished assortment is meant to steer researchers for future years.

Download e-book for kindle: MicroRNAs in Cancer by César López-Camarillo, Laurence A. Marchat

MicroRNA (miRNA) biology is a state-of-the-art subject in easy in addition to biomedical learn. this can be a really good booklet targeting the present knowing of the position of miRNAs within the improvement, development, invasion, and metastasis of numerous varieties of melanoma. It additionally experiences their capability for purposes in melanoma analysis, analysis, and healing goals in addition to the aptitude use in translational medication.

Get Stem Cells. Scientific Facts and Fiction PDF

The second one version of Stem Cells: clinical proof and Fiction presents the non-stem telephone professional with an comprehensible evaluate of the heritage, present scenario, and evidence and fiction of the guarantees of stem cells. development on good fortune of its award-winning previous variation, the second one version beneficial properties new chapters on embryonic and iPS cells and stem cells in veterinary technology and medication.

Additional resources for ABC Transporters: Biochemical, Cellular, and Molecular Aspects

Example text

1) are predicted to fold together in a way similar to the model protein and to produce the ATP-binding pocket, but the large, middle part of the protein containing about 90 amino acid residues was excluded entirely from this pocket structure in at least one model. 39 This portion, often called the helical d o m a i n , and a linker region that connects the C-terminal end of the helical domain to the ATPase portion of the molecule (Fig. 1) are hypothesized to be important in coupling A T P hydrolysis to conformational changes in the channel portion of the transporter, u Interestingly, several mutations in HisP that uncouple A T P hydrolysis from solute translocation are indeed located in this linker region as well as at the beginning of the second ATP-binding region, a° Some of the ATP-binding subunits apparently perform additional functions.

A. Shuman and co-workers, 52 of E. coli mutants that no longer require the presence of M B P for the transport of maltose. These mutants are altered in the integral m e m b r a n e proteins MalF or MalG, and transport maltose specifically. The affinity for maltose, however, is much lower, and the transport Km for maltose is about 1 raM, in contrast to the transport Kin, about 1/xM, of the wild-type transport system that includes MBP. All MBP-independent mutants contain two mutations either in m a l F or m a l G .

Shuman, J. Mol. Biol. 233, 659 (1993). [11 BACTERIALABC TRANSPORTERS 13 ABC transporters, possibly their channel domains, and the helper proteins (see Table I) play no role in the specificityF Recently, random mutagenesis of helices 6, 7, and 8 of MalF was carried out by Ehrle et aL 58 Many mutations, clustered on one face of helix 6, changed the specificity of transport, again showing that the channel protein contributes to substrate specificity. Many of them transported maltoheptaose but not maltose.

Download PDF sample

ABC Transporters: Biochemical, Cellular, and Molecular Aspects by John N. Abelson, Melvin I. Simon, Suresh V. Ambudkar, Michael M. Gottesman


by Ronald
4.2

Rated 4.38 of 5 – based on 31 votes